https://www.theragnostics.no/en/author/giulia-santo/ Giulia Santo Hugo Blox Builder (https://hugoblox.com)en-usMon, 09 Dec 2024 00:00:00 +0000 https://www.theragnostics.no/media/icon_hu14557955862192370321.png https://www.theragnostics.no/en/author/giulia-santo/ https://www.theragnostics.no/en/publications/cicone-2024-do/ Mon, 09 Dec 2024 00:00:00 +0000 https://www.theragnostics.no/en/publications/cicone-2024-do/ <hr> <p>Radiopharmaceutical theranostic treatments have grown exponentially worldwide, and internal dosimetry has attracted attention and resources. Despite some similarities with chemotherapy, radiopharmaceutical treatments are essentially radiotherapy treatments, as the release of radiation into tissues is the determinant of the observed clinical effects. Therefore, absorbed dose calculations are key to explaining dose-effect correlations and individualizing radiopharmaceutical treatments. The present article introduces the basic principles of internal dosimetry and provides an overview of available loco-regional and systemic radiopharmaceutical treatments for central nervous system (CNS) tumors. The specific characteristics of dosimetry as applied to these treatments are highlighted, along with their limitations and most relevant results. Dosimetry is performed with higher precision and better reproducibility than in the past, and dosimetric data should be systematically collected, as treatment planning and verification may help exploit the full potential of theranostic of CNS tumors.</p> https://www.theragnostics.no/en/publications/cicone-2023-radioimmunotherapy/ Mon, 01 May 2023 00:00:00 +0000 https://www.theragnostics.no/en/publications/cicone-2023-radioimmunotherapy/ <hr> <p>Systemic radioimmunotherapy (RIT) is arguably the most effective and least toxic anticancer treatment for non-Hodgkin lymphoma (NHL). In treatment-naïve patients with indolent NHL, the efficacy of a single injection of RIT compares with that of multiple cycles of combination chemotherapy. However, 20 years following the approval of the first CD20-targeting radioimmunoconjugates ⁹⁰Y-Ibritumomab-tiuxetan (Zevalin) and ¹³¹I-tositumomab (Bexxar), the number of patients referred for RIT in western countries has dramatically decreased. Notwithstanding this, the development of RIT has continued. Therapeutic targets other than CD20 have been identified, new vector molecules have been produced allowing for faster delivery of RIT to the target, and innovative radionuclides with favorable physical characteristics such as alpha emitters have been more widely available. In this article, we reviewed the current status of RIT in NHL, with particular focus on recent clinical and preclinical developments.</p>